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PathogenDx Expands Reach of Its Patented Multiplexed Molecular Testing Technology, Bringing It to the Clinical, Food and Agriculture Sectors

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Company’s Novel “Dynamic Dimensional Detection” Array Technology Delivers Unprecedented Performance in Multiplexing, Turn-Around Time, Throughput and Cost Per Test

Scottsdale, Arizona–(Newsfile Corp. – April 12, 2023) – PathogenDx (“PathogenDx” or “Company”), a leader in next-generation microarray technology for better health and safety, announced it has expanded the reach of its patented multiplexed molecular testing technology – Dynamic Dimensional Detection (“D3 Array™”) – beyond the cannabis and hemp sectors. The Company is bringing its D3 Array™, which addresses the challenges microarray technology has suffered in prior generations as well as the gap that qPCR and next-generation sequencing (“NGS”) has created in multiplexing, performance, throughput and cost, to the clinical, food and agriculture sectors.

The Company’s proprietary D3 Array™ features a flexible, open, lattice-like architecture that is rich with highly accessible target-probe binding sites. The benefit of this is the ability of amplicon targets to: move easily through the 3D structure; locate target:probe binding sites; and bind more easily with significantly reduced steric hindrance. Consequently, the duplex pairing hybridization reaction is rapid at room temperature and delivers high sensitivity and specificity results to labs and their clients.

“Today, even with two well-established diagnostic technologies, there are instances where sensitivity and multiplexing limitations of the well-adopted qPCR are insufficient and the costs, turn-around time and heavy lifting needed for bioinformatics of NGS are problematic in the clinical, food and agricultural sectors,” said PathogenDx Co-founder and CEO Milan Patel. “For example, in the traditional array, a probe monolayer is printed directly onto a surface, and typically the probe is much smaller than the amplicon itself, which provides limited binding access to the much longer amplicon target. This essentially reduces target binding affinity due to surface crowding. In contrast, our D3 Array™ features a 3D cross-linked lattice structure with surface-bound oligonucleotide probes accessible throughout the 3D structure, thus increasing access and allowing for a faster, higher affinity target amplicon binding reaction.”

Patel added, “The D3 Array™ has emerged as our core of the technology platform, and the tests built upon it are in commercial deployment in more than 100 regulated laboratories. Additionally, our D3 Array™ is a more flexible, higher throughput and cost-effective approach than a series of multiplex qPRC/PCR assays. It also delivers a much faster and more affordable alternative to NGS, delivering high specificity, but without the complex sample prep, data analysis and reporting encumbered with NGS.”

Lux Diagnostics CEO and Founder Dr. Jonathan Goss said, “PathogenDx D3 Array™ provides the best-of-both-worlds alternative. It holds promise in clinical diagnostics, where accelerating medical diagnosis and saving money are high priorities. We have been able to run PathogenDx’s Detectx-Cv kit for COVID variant testing for more than a year, and at some points the platform was able to process 1,200 samples a day in variant identification. The D3 Array™ allowed us to get single gene mutation level identification on positive COVID samples in a single day, whereas NGS would have taken weeks. This is the promise that PathogenDx technology holds in terms of addressing other clinical diagnostics areas where there is a large unmet need in throughput, cost, accuracy and time to yield results.”

PathogenDx’s D3 Array™ is readily adaptable to high throughput 96-well plate processing from sample to answer. Using standard lab equipment and basic PCR lab-tech proficiency, the D3 Array™ features include:

  • 3D cross-linked, flexible architecture
  • Increased access to target:probe binding sites
  • Solution-like target:probe binding interaction
  • Room temperature hybridization
  • High affinity
  • Minimized non-specific surface crowding
  • Increases fidelity to enable SNP level detection

For more information, visit https://pathogendx.com/science/.

About PathogenDx
Headquartered in Scottsdale, Arizona, PathogenDx is a leader in next-generation microarray technology for better health and safety. Its mission is to become the new standard in DNA-based testing through widespread adoption of its advanced microarray testing platform for the human diagnostics, food and agricultural industries. PathogenDx’s technology can rapidly identify and detect up to 50 pathogens all in a single test, in six hours providing triplicate data per analyte for certainty in results with a simple and easy process. The company’s DNA-testing products – Detectx™, Quantx™, Envirox™ and D3 Array™- are disrupting the century old practice of petri dish testing to identify, detect and quantify pathogens that threaten human health, our ecosystem and the environment. This technology will help growing businesses deliver safer products leading to healthier lives, while preventing billions of dollars in losses from infection and contamination. For more information on how you can utilize this simple, powerful and inexpensive DNA-based pathogen testing, visit www.pathogendx.com.

Media Contacts:
Ellen Mellody
570-209-2947
[email protected]

Michela Proto
914-907-3670
[email protected]

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/162020

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