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State Street Global Advisors Announces Planned Change to SPDR® ETF Lineup

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BOSTON–(BUSINESS WIRE)–State Street Global Advisors, the asset management business of State
Street Corporation (NYSE: STT), today announced plans to close and
liquidate the SPDR® MSCI China A Shares IMI ETF (XINA) based
on an ongoing review of the SPDR® ETF offering and listening
to client feedback.

The final day for creations will be May 29, 2019. Trading of all shares
will be suspended on the NYSE Arca at the open of market on May 30,
2019, and proceeds of the liquidation are scheduled to be sent to
shareholders on or about June 6, 2019. For additional information on the
liquidation, shareholders of the funds can visit www.spdrs.com.

About SPDR® Exchange Traded Funds

SPDR® ETFs are a comprehensive family spanning an array of
international and domestic asset classes. SPDR® ETFs are
managed by SSGA Funds Management, Inc., a registered investment adviser
and wholly owned subsidiary of State Street Corporation. The funds
provide investors with the flexibility to select investments that are
precisely aligned to their investment strategy. Recognized as an
industry pioneer, State Street created the first US listed ETF in 1993
(SPDR S&P 500® – Ticker SPY) and has remained on the forefront of
responsible innovation, as evidenced by the introduction of many
ground-breaking products, including first-to-market launches with gold,
international real estate, international fixed income, and sector ETFs.
For more information, visit www.spdrs.com.

About State Street Global Advisors

For four decades, State Street Global Advisors has served the world’s
governments, institutions and financial advisors. With a rigorous,
risk-aware approach built on research, analysis and market-tested
experience, we build from a breadth of active and index strategies to
create cost-effective solutions. As stewards, we help portfolio
companies see that what is fair for people and sustainable for the
planet can deliver long-term performance. And, as pioneers in index,
ETF, and ESG investing, we are always inventing new ways to invest. As a
result, we have become the world’s third largest asset manager with
nearly US $2.80 trillion* under our care.

* This figure is presented as of March 31, 2019 and includes
approximately $33 billion of assets with respect to SPDR products for
which State Street Global Advisors Funds Distributors, LLC (SSGA FD)
acts solely as the marketing agent. SSGA FD and State Street Global
Advisors are affiliated.

Important Risk Information

Investing involves risk, including the risk of loss of principal.

ETFs trade like stocks, are subject to investment risk, fluctuate
in market value and may trade at prices above or below the ETFs net
asset value. Brokerage commissions and ETF expenses will reduce returns.

Chinese securities A shares involves certain investments risks
and investment considerations including, (i) the small size of the
market for Chinese securities relative to the US market, low volume of
trading relative to U.S. securities, lack of liquidity and in price
volatility, (ii) currency devaluations and other currency exchange rate
fluctuations or blockage, (iii) the nature and extent of intervention by
the Chinese government in the Chinese securities markets, whether such
intervention will continue and the impact of such intervention or its
discontinuation, (iv) the ability of Chinese issuers to unilaterally
suspend trading of their securities, and (v) custody risks associated
with investing through a RQFII.

Derivative investments may involve risks such as potential
illiquidity of the markets and additional risk of loss of principal.

Concentrated investments in a particular industry or sector may
be more vulnerable to adverse changes in that industry or sector.

Foreign (non-U.S.) securities may be subject to greater
political, economic, environmental, credit and information risks.
Foreign securities may be subject to higher volatility than U.S.
securities, due to varying degrees of regulation and limited liquidity.
These risks are magnified in emerging markets.

Equity securities may fluctuate in value in response to the
activities of individual companies and general market and economic
conditions.

Non-diversified funds that focus on a relatively small number of
securities tend to be more volatile than diversified funds and the
market as a whole.

Passively managed funds hold a range of securities that, in the
aggregate, approximates the full Index in terms of key risk factors and
other characteristics. This may cause the fund to experience tracking
errors relative to performance of the index.

State Street Global Advisors and its affiliates (“SSGA”) have not
taken into consideration the circumstances of any particular investor in
producing this material and are not making an investment recommendation
or acting in fiduciary capacity in connection with the provision of the
information contained herein.

Standard & Poor’s, S&P and SPDR are registered trademarks of Standard &
Poor’s Financial Services LLC, a division of S&P Global (“S&P”); Dow
Jones is a registered trademark of Dow Jones Trademark Holdings LLC (Dow
Jones); and these trademarks have been licensed for use by S&P Dow Jones
Indices LLC (SPDJI) and sublicensed for certain purposes by State Street
Corporation. State Street Corporation’s financial products are not
sponsored, endorsed, sold or promoted by SPDJI, Dow Jones, S&P, their
respective affiliates and third party licensors and none of such parties
make any representation regarding the advisability of investing in such
product(s) nor do they have any liability in relation thereto, including
for any errors, omissions, or interruptions of any index.

Distributor: State Street Global Advisors Funds Distributors,
LLC, member FINRA, SIPC

Before investing, consider the fund’s investment objectives, risks,
charges and expenses. To obtain a prospectus or summary prospectus which
contains this and other information, call 866.787.2257 or visit
spdrs.com. Read it carefully.

Not FDIC Insured • No Bank Guarantee • May Lose Value

2517820.1.1.GBL.RTL

Contacts

Olivia Offner
+1 617.662.0198
[email protected]


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Innocan

Innocan Pharma Reports Breakthrough in a Pre-Clinical Trial: Liposomal-CBD Injection Restores Mobility to an Amputee Female Donkey

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innocan-pharma-reports-breakthrough-in-a-pre-clinical-trial:-liposomal-cbd-injection-restores-mobility-to-an-amputee-female-donkey

HERZLIYA, Israel and ALGARY, AB, May 9, 2024 /PRNewswire/ — Innocan Pharma Corporation (CSE: INNO) (FSE: IP4) (OTCQB: INNPF) (“Innocan” or the “Company”), a pioneer in the pharmaceutical and biotechnology industries, is pleased to announce the successful pre-clinical treatment with a liposomal-CBD injection in a female donkey. Innocan’s innovative therapy provided immediate noticeable pain relief and improved mobility.

Miri, a 7-year-old female donkey, underwent amputation of her right front limb at a young age, resulting in a weight burden primarily borne by her left front limb. Consequently, she developed laminitis in her left front limb, an inflammatory disease affecting the soft tissue that connects the foot bone to the hoof, seemingly causing extreme pain and limited mobility. Over time, Miri’s condition worsened, culminating in the formation of a abscess in the affected hoof, which appeared to have intensified her pain. Despite receiving pain relief medications, Miri found no respite, was unable to move, and her caregivers were advised to euthanize her.

As an act of compassionate therapy, the female donkey was administered a liposomal-CBD injection. The effect was immediate, with Miri becoming active and roaming the farm. Following the liposomal-CBD injection, the abscess in her affected foot healed, and Miri regained her ability to walk and move as she did before her laminitis developed.

“Thanks to our innovative liposomal-CBD injection, we are thrilled to have brought relief to Miri, eliminating the need for euthanasia,” commented Iris Bincovich, CEO of Innocan. “Once again, Innocan has shown liposomal-CBD to be effectively active for pain relief and well-being. We see this pre-clinical treatment as strong evidence of liposomal-CBD’s potential to improve the lives of animal patients and potentially human patients.”

“Laminitis is a crippling condition well familiar and common in horses,” said Prof Chezy Barenholz, the Chief Scientific Officer of Innocan. “The disease results in severe pain condition, representing another big market for liposomal-CBD with great potential to treat horses. Innocan is dedicated to advancing the development of CBD-based therapeutics for various indications in both humans and animals.”

For further information and a supporting video, please see: https://youtu.be/Hgqh2WOlwJQ?si=oGgSYrGi3rkW-RC

About Innocan Pharma:

Innocan is a pharmaceutical tech company that operates under two main segments: Pharmaceuticals and Consumer Wellness. In the Pharmaceuticals segment, Innocan focuses on developing innovative drug delivery platform technologies comprises with cannabinoids science, to treat various conditions to improve patients’ quality of life. This segment involves two drug delivery technologies: (i) LPT CBD-loaded liposome platform facilitating exact dosing and the prolonged and controlled release of CBD into the blood stream. The LPT delivery platform research is in the preclinical trial phase for two indications: Epilepsy and Pain Management. In the Consumer Wellness segment, Innocan develops and markets a wide portfolio of innovative and high-performance self-care products to promote a healthier lifestyle. Under this segment Innocan has established a Joint Venture by the name of BI Sky Global Ltd. that focuses developing on advanced targeted online sales. https://innocanpharma.com/

Contact Information:

For Innocan Pharma Corporation:

Iris Bincovich, CEO

+1 5162104025

+972-54-3012842

+442037699377

[email protected]

NEITHER THE CANADIAN SECURITIES EXCHANGE NOR ITS REGULATION SERVICES PROVIDER HAVE REVIEWED OR ACCEPT RESPONSIBILITY FOR THE ADEQUACY OR ACCURACY OF THIS RELEASE.

Caution Regarding Forward-Looking Information

Certain information set forth in this news release, including, without limitation, the Company’s plans for human trials of its LPT-CBD platform, is forward-looking information within the meaning of applicable securities laws. By its nature, forward-looking information is subject to numerous risks and uncertainties, some of which are beyond Innocan’s control. . The forward-looking information contained in this news release is based on certain key expectations and assumptions made by Innocan, including expectations and assumptions concerning the anticipated benefits of the products, satisfaction of regulatory requirements in various jurisdictions and satisfactory completion of production and distribution arrangements.

Forward-looking information is subject to various risks and uncertainties that could cause actual results and experience to differ materially from the anticipated results or expectations expressed in this news release. The key risks and uncertainties include but are not limited to: global and local (national) economic, political, market and business conditions; governmental and regulatory requirements and actions by governmental authorities; and potential disruption of relationships with suppliers, manufacturers, customers, business partners and competitors. There are also risks that are inherent in the nature of product distribution, including import/export matters and the failure to obtain any required regulatory and other approvals (or to do so in a timely manner). The anticipated timeline for entry to markets may change for a number of reasons, including the inability to secure necessary regulatory requirements, or the need for additional time to conclude and/or satisfy the manufacturing and distribution arrangements. As a result of the foregoing, readers should not place undue reliance on the forward-looking information contained in this news release. A comprehensive discussion of other risks that impact Innocan can be found in Innocan’s public reports and filings which are available under Innocan’s profile at www.sedarplus.ca.

Readers are cautioned that undue reliance should not be placed on forward-looking information as actual results may vary materially from the forward-looking information. Innocan does not undertake to update, correct or revise any forward-looking information as a result of any new information, future events or otherwise, except as may be required by applicable law.

Logo: https://mma.prnewswire.com/media/2046271/3968398/Innocan_Pharma_Corporation_Logo.jpg

Cision View original content:https://www.prnewswire.co.uk/news-releases/innocan-pharma-reports-breakthrough-in-a-pre-clinical-trial-liposomal-cbd-injection-restores-mobility-to-an-amputee-female-donkey-302141590.html

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